Analysis of ABC Transporter Gene Expression in Atherosclerosis

ABC transporters are a large family of membrane proteins that transport chemically diverse substrates across the cell membrane. Disruption mechanisms mediated by causes development various diseases, including atherosclerosis. Methods: A bioinformatic analysis dataset from Gene Expression Omnibus (GEO) was performed. GEO containing data on gene expression levels in samples atherosclerotic lesions and control arteries without carotid, femoral, infrapopliteal used for analysis. To evaluate differentially expressed genes, performed comparison groups using limma package R (v. 4.0.2) GEO2R Phantasus tools 1.11.0). Results: The obtained indicate differential many belonging to different subfamilies. expressions transporter genes involved lipid transport, multidrug resistance, ion exchange shown. Differences tissue established. Conclusions: demonstrates differences normal arteries, which may involvement pathogenesis